Brain Enhancement and Support

Research & Studies

Molecular hydrogen is protective against 6-hydroxydopamine-induced nigrostriatal degeneration in a rat model of Parkinson's disease

 

“Molecular hydrogen serves as an antioxidant that reduces hydroxyl radicals, but not the other reactive oxygen and nitrogen species. This study suggests that hydrogen water is likely able to retard the development and progression of Parkinson's disease.”

 

Yuan, F., Ito, M., Fujita, Y., Ito, M., Ichihara, M., Masuda, A., . . . Ohno, K. (2009). Molecular hydrogen is protective against 6-hydroxydopamine-induced nigrostriatal degeneration in a rat model of Parkinson’s disease. Neuroscience Letters, 453(2), 81-85. doi: 10.1016/j.neulet.2009.02.016

 

Hydrogen in drinking water reduces dopaminergic neuronal loss in the 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine mouse model of Parkinson's disease

 

“Chronic oxidative stress causes neurodegenerative diseases such as Parkinson's disease (PD). The results of this study indicated that low concentration of H2 in drinking water can reduce oxidative stress in the brain. Thus, drinking H2-containing water may be useful in daily life to prevent or minimize the risk of life style-related oxidative stress and neurodegeneration.”

 

Fujita, K., Seike, T., Yutsudo, N., Ohno, M., Yamada, H., Yamaguchi, H., . . . Noda, M. (2009). Hydrogen in drinking water reduces dopaminergic neuronal loss in the 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine mouse model of Parkinson's disease. PLOS ONE, 4(9). 1-10. doi: 10.1371/journal.pone.0007247

 

 

Inhalation of hydrogen gas attenuates cognitive impairment in transient cerebral ischemia via inhibition of oxidative stress

 

“Inhalation of hydrogen gas could attenuate cognitive impairment in the ischemic rats. This protection is associated with decreased neuronal death in CA1 region and inhibition of oxidative stress.”

 

Ge, P., Zhao, J., Li, S., Ding, Y., Yang, G., & Luo, Y. (2012). Inhalation of hydrogen gas attenuates cognitive impairment in transient cerebral ischemia via inhibition of oxidative stress. Neurological Research, 34(2), 187-194. doi: 10.1179/1743132812y.0000000002

 

 

Drinking hydrogen water ameliorated cognitive impairment in senescence-accelerated mice

 

“In this study, scientists investigated the efficacies of drinking hydrogen water for prevention of spatial memory decline and age-related brain alterations using mice that exhibited early aging syndromes including declining learning ability and memory. However, treatment with hydrogen water for 30 days prevented age-related declines in cognitive ability. In addition, drinking hydrogen water for 18 weeks inhibited neurodegeneration in hippocampus, while marked loss of neurons was noted in control, aged brains of mice receiving regular water. On the basis of these results, hydrogen water merits further investigation for possible therapeutic/preventative use for age-related cognitive disorders.”

 

Gu, Y., Huang, C., Inoue, T., Yamashita, T., Ishida, T., Kang, K., & Nakao, A. (2010). Drinking hydrogen water ameliorated cognitive impairment in senescence-accelerated mice. Journal of Clinical Biochemistry and Nutrition, 46(3), 269-276. doi: 10.3164/jcbn.10-19

 

 

Electrochemically reduced water protects neural cells from oxidative damage

 

“Electrochemically reduced water (ERW), which contains small amounts of molecular hydrogen, was demonstrated to scavenge reactive oxygen species (ROS) in several cell types. This study collectively demonstrated for the first time that ERW protects several types of neuronal cells by scavenging ROS because of the presence of hydrogen and platinum nanoparticles dissolved in ERW.”

 

Kashiwagi, T., Yan, H., Hamasaki, T., Kinjo, T., Nakamichi, N., Teruya, K., . . . Shirahata, S. (2014). Electrochemically reduced water protects neural cells from oxidative damage. Oxidative Medicine and Cellular Longevity, 2014(869121), 1-18. doi: 10.1155/2014/869121

 

 

Hydrogen-rich saline improves memory function in a rat model of amyloid-beta-induced Alzheimer's disease by reduction of oxidative stress

 

“Hydrogen-rich saline prevented amyloid beta-induced neuroinflammation and oxidative stress, which may contribute to the improvement of memory dysfunction in this rat model.”

 

Li, J., Wang, C., Zhang, J. H., Cai, J., Cao, Y., & Sun, X. (2010). Hydrogen-rich saline improves memory function in a rat model of amyloid-beta-induced Alzheimer's disease by reduction of oxidative stress. Brain Research, 1328, 152-161. doi: 10.1016/j.brainres.2010.02.046 

 

Molecular Hydrogen and its potential application in therapy of brain disorders

 

“One of the reasons why molecular hydrogen may be so Neuroprotective is due to its ability to diffuse through the blood-brain barrier and penetrate biomembranes to diffuse into organelles such as the mitochondria and nucleus. In particular, the diffusion into mitochondria is very important considering they are a major source of reactive oxygen species and very difficult to target. Molecular hydrogen also shows a protective effect on the mitochondria themselves.”

 

Ma, F. X. (2015). Molecular hydrogen and its potential application in therapy of brain disorders. Brain Disorders & Therapy, 4(1), 1-2. doi: 10.4172/2168-975x.1000154

 

 

Hydrogen inhalation is neuroprotective and improves functional outcomes in mice after intracerebral hemorrhage

 

“The results of this study suggest molecular hydrogen inhalation exerts an acute brain-protective effect in mice.”

 

Manaenko, A., Lekic, T., Ma, Q., Ostrowski, R. P., Zhang, J. H., & Tang, J. (2011). Hydrogen inhalation is neuroprotective and improves functional outcomes in mice after intracerebral hemorrhage. Acta Neurochirurgica Supplementum, 111, 179-183. doi: 10.1007/978-3-7091-0693-8_30

 

 

Oral 'hydrogen water' induces neuroprotective ghrelin secretion in mice

 

“H₂ supplementation increases gastric expression of mRNA encoding ghrelin, a growth hormone secretagogue, and ghrelin secretion. Strikingly, the neuroprotective effect of H₂ water was abolished by either administration of the ghrelin receptor-antagonist, D-Lys(3) GHRP-6, or atenolol. Thus, the neuroprotective effect of H₂ in PD is mediated by enhanced production of ghrelin. Our findings point to potential, novel strategies for ameliorating pathophysiology in which a protective effect of H₂ supplementation has been demonstrated.”

 

Matsumoto, A., Yamafuji, M., Tachibana, T., Nakabeppu, Y., Noda, M., & Nakaya, H. (2013). Oral ‘hydrogen water’ induces neuroprotective ghrelin secretion in mice. Scientific Reports, 3(3273), 1-5. doi: 10.1038/srep03273

 

 

Consumption of molecular hydrogen prevents the stress-induced impairments in hippocampus-dependent learning tasks during chronic physical restraint in mice

 

“Consumption of hydrogen water ad libitum throughout this study suppressed the increase in the oxidative stress markers and prevented cognitive impairment. Continuous consumption of hydrogen water reduces oxidative stress in the brain, and prevents the stress-induced decline in learning and memory caused by chronic physical restraint. Hydrogen water may be applicable for preventive use in cognitive or other neuronal disorders.”

 

Nagata, K., Nakashima-Kamimura, N., Mikami, T., Ohsawa, I., & Ohta, S. (2008). Consumption of molecular hydrogen prevents the stress-induced impairments in hippocampus-dependent learning tasks during chronic physical restraint in mice. Neuropsychopharmacology, 34(2), 501-508. doi: 10.1038/npp.2008.95

 

Recent progress toward hydrogen medicine: Potential of molecular hydrogen for preventive and therapeutic applications

 

“Chronic oxidative stress is one of the major causes of most lifestyle-related diseases, cancer and the aging process and acute oxidative stress directly causes serious damage to tissues. Despite the clinical importance of oxidative damage, therapy with antioxidants have not been particularly successful. Molecular hydrogen (H2) has potential as a new and powerful antioxidant in preventive and therapeutic applications. H2 has a number of advantages as a potential antioxidant: H2 rapidly diffuses into tissues and cells, and it is mild enough neither to disturb metabolic redox reactions nor to affect reactive oxygen species (ROS) that function in cell signaling, thereby, there should be little adverse effects of consuming H2. H2 shows not only effects against oxidative stress, but also various anti-inflammatory and anti-allergic effects. H2 regulates various gene expressions and protein-phosphorylations as well.”

 

Ohta, S. (2011). Recent progress toward hydrogen medicine: Potential of molecular hydrogen for preventive and therapeutic applications. Current Pharmaceutical Design, 17(22), 2241-2252. doi: 10.2174/138161211797052664

 

 

Hydrogen-rich pure water prevents superoxide formation in brain slices of vitamin C-depleted SMP30/GNL knockout mice.

 

“Hydrogen is an established anti-oxidant that prevents acute oxidative stress. This study shows that hydrogen-rich pure water acts as an anti-oxidant in the brain and prevents superoxide formation.”

 

Sato, Y., Kajiyama, S., Amano, A., Kondo, Y., Sasaki, T., Handa, S., . . . Ishigami, A. (2008). Hydrogen-rich pure water prevents superoxide formation in brain slices of vitamin C-depleted SMP30/GNL knockout mice. Biochemical and Biophysical Research Communications, 375(3), 346-350. doi: 10.1016/j.bbrc.2008.08.020

 

 

Hydrogen improves neurological function through attenuation of blood–brain barrier disruption in spontaneously hypertensive stroke-prone rats

 

“This study suggests that ingestion of hydrogen-rich water can improve neurological function due to its ability to penetrate the blood-brain barrier and neutralize reactive oxygen species.”

 

Takeuchi, S., Nagatani, K., Otani, N., Nawashiro, H., Sugawara, T., Wada, K., & Mori, K. (2015). Hydrogen improves neurological function through attenuation of blood–brain barrier disruption in spontaneously hypertensive stroke-prone rats. BioMed Central Neuroscience, 16(22), 1-13. doi: 10.1186/s12868-015-0165-3

 

 

Hydrogen-rich saline reduces oxidative stress and inflammation by inhibit of JNK and NF-κB activation in a rat model of amyloid-beta-induced Alzheimer's disease

 

“Hydrogen-rich saline prevented amyloid beta-induced neuroinflammation and oxidative stress in this rat model.”

 

Wang, C., Li, J., Liu, Q., Yang, R., Zhang, J. H., Cao, Y., & Sun, X. (2011). Hydrogen-rich saline reduces oxidative stress and inflammation by inhibit of JNK and NF-κB activation in a rat model of amyloid-beta-induced Alzheimer's disease. Neuroscience Letters, 491(2), 127-132. doi: 10.1016/j.neulet.2011.01.022

© 2018 trusii. All Rights Reserved

The statements on this website have not been evaluated by the Food and Drug Administration.
The products on this website are not intended to diagnose, treat, cure, or prevent any disease.