Caridovascular Health
Research & Studies

The potential cardioprotective effects of hydrogen in irradiated mice

 

“In this paper, we demonstrate that hydrogen can protect myocardium degeneration from radiation-induced injury, decrease myocardium malondialdehyde (MDA), 8-hydroxydeoxyguanosine (8-OHdG) levels, and increase myocardium endogenous antioxidants in vivo. We suggest that hydrogen has a cardioprotective effect against radiation induced injury.”

 

Qian, L., Cao, F., Cui, J., Wang, Y., Huang, Y., Chuai, Y., . . . Cai, J. (2010). The potential cardioprotective effects of hydrogen in irradiated mice. Journal of Radiation Research, 51(6), 741-747. doi: 10.1269/jrr.10093

 

Anti-inflammatory effect of hydrogen-rich saline in a rat model of regional myocardial ischemia and reperfusion

 

“Attenuated the increase of I/R induced proinflammatory cytokine tumor necrosis factor-α (TNF-a) and interleukin-1β (IL-1b) levels in the AAR. H(2) saline has an anti-inflammatory effect on rat hearts with regional myocardial I/R.”

 

Zhang, Y., Sun, Q., He, B., Xiao, J., Wang, Z., & Sun, X. (2011). Anti-inflammatory effect of hydrogen-rich saline in a rat model of regional myocardial ischemia and reperfusion. International Journal of Cardiology, 148(1), 91-95. doi: 10.1016/j.ijcard.2010.08.058

 

Hydrogen-rich saline protects myocardium against ischemia/reperfusion injury in rats

 

“The heart function parameters including left ventricular systolic pressure (LVSP), left ventricular diastolic pressure (LVDP), +(dP/dt)(max) and -(dP/dt)(max) were also significantly improved 24 h after reperfusion. It is concluded that hydrogen-rich saline is a novel, simple, safe, and effective method to attenuate myocardial I/R injury.”

 

Sun, Q., Kang, Z., Cai, J., Liu, W., Liu, Y., Zhang, J. H., . . . Sun, X. (2009). Hydrogen-rich saline protects myocardium against ischemia/reperfusion injury in rats. Experimental Biology and Medicine, 234(10), 1212-1219. doi: 10.3181/0812-rm-349

 

Inhalation of hydrogen gas reduces infarct size in the rat model of myocardial ischemia-reperfusion injury

 

“Inhalation of H(2) gas at incombustible levels during ischemia and reperfusion reduces infarct size without altering hemodynamic parameters, thereby preventing deleterious left ventricular remodeling. Thus, inhalation of H(2) gas is promising strategy to alleviate ischemia-reperfusion injury coincident with recanalization of coronary artery.”

 

Hayashida, K., Sano, M., Ohsawa, I., Shinmura, K., Tamaki, K., Kimura, K., . . . Fukuda, K. (2008). Inhalation of hydrogen gas reduces infarct size in the rat model of myocardial ischemia–reperfusion injury. Biochemical and Biophysical Research Communications, 373(1), 30-35. doi: 10.1016/j.bbrc.2008.05.165

 

Molecular hydrogen alleviates cellular senescence in endothelial cells

 

“Substantial evidence indicates that molecular hydrogen (H2) has beneficial vascular effects because of its antioxidant and/or anti-inflammatory effects. H2 has long-lasting antioxidant and anti-aging effects on vascular endothelial cells through the Nrf2 pathway, even after transient exposure to H2. Hydrogen-rich water may thus be a functional drink that increases longevity.”

 

Hara, F., Tatebe, J., Watanabe, I., Yamazaki, J., Ikeda, T., & Morita, T. (2016). Molecular hydrogen alleviates cellular senescence in endothelial cells. Circulation Journal, 80(9), 2037-2046. doi: 10.1253/circj.cj-16-0227

 

The evolution of molecular hydrogen: A noteworthy potential therapy with clinical significance

 

“Hydrogen is qualified to cross the blood brain barrier, to enter the mitochondria, and even has the ability to translocate to the nucleus under certain conditions. Once in these ideal locations of the cell, previous studies have shown that hydrogen exerts antioxidant, anti-apoptotic, anti-inflammatory, and cytoprotective properties that are beneficial to the cell.”

 

Dixon, B. J., Tang, J., & Zhang, J. H. (2013). The evolution of molecular hydrogen: A noteworthy potential therapy with clinical significance.  ​Medical Gas Research, 3(10), 1-12. doi: 10.1186/2045-9912-3-10​  

 

​Hydrogen-rich water prevents lipid deposition in the descending aorta in a rat periodontitis model

 

“Hydrogen Water intake may prevent lipid deposition in the rat aorta induced by periodontitis by decreasing serum ox-LDL levels and aortic oxidative stress.”

 

Ekuni, D., Tomofuji, T., Endo, Y., Kasuyama, K., Irie, K., Azuma, T., . . . Morita, M. (2012). Hydrogen-rich water prevents lipid deposition in the descending aorta in a rat periodontitis model. Archives of Oral Biology, 57(12), 1615-1622. doi: 10.1016/j.archoralbio.2012.04.013

 

Inhalation of hydrogen gas attenuates left ventricular remodeling induced by intermittent hypoxia in mice

 

“Inhalation of H(2) gas was effective for reducing oxidative stress and preventing Left Ventricular remodeling induced by intermittent hypoxia relevant to sleep apnea.”

Hayashi, T., Yoshioka, T., Hasegawa, K., Miyamura, M., Mori, T., Ukimura, A., . . . Ishizaka, N. (2011). Inhalation of hydrogen gas attenuates left ventricular remodeling induced by intermittent hypoxia in mice. American Journal of Physiology: Heart and Circulatory Physiology, 301(3), doi: 10.1152/ajpheart.00150.2011 

 

​Cardioprotective effect of hydrogen-rich saline on isoproterenol-induced myocardial infarction in rats

“From these results, hydrogen-rich saline exerts cardiovascular protective effects against isoproterenol-induced myocardial infarction at least in part via interactions which evoke antioxidant and anti-inflammatory activities.”

 

Jing, L., Wang, Y., Zhao, X., Zhao, B., Han, J., Qin, S., & Sun, X. (2015). Cardioprotective effect of hydrogen-rich saline on isoproterenol-induced myocardial infarction in rats. Heart, Lung and Circulation, 24(6), 602-610. doi: 10.1016/j.hlc.2014.11.018 

 

​Hydrogen-rich saline improves survival and neurological outcome after cardiac arrest and cardiopulmonary resuscitation in rats

 

“Hydrogen-rich saline treatment improved survival and neurological outcome after cardiac arrest/resuscitation in rats, which was partially mediated by reducing oxidative stress, inflammation, and apoptosis.”

                            

Huo, T., Zeng, Y., Liu, X., Sun, L., Han, H., Chen, H., . . . Xiong, L. (2014). Hydrogen-rich saline improves survival and neurological outcome after cardiac arrest and cardiopulmonary resuscitation in rats. Anesthesia & Analgesia, 119(2), 368-380. doi: 10.1213/ane.0000000000000303 

 

​Hydrogen-supplemented drinking water protects cardiac allografts from inflammation-associated deterioration

 

“Drinking hydrogen water prolongs survival of cardiac allografts and reduces intimal hyperplasia of aortic allografts.”

 

Noda, K., Tanaka, Y., Shigemura, N., Kawamura, T., Wang, Y., Masutani, K., . . . Nakao, A. (2012). Hydrogen-supplemented drinking water protects cardiac allografts from inflammation-associated deterioration. Transplant International, 25(12), 1213-1222. doi: 10.1111/j.1432-2277.2012.01542.x 

 

​Hydrogen acts as a therapeutic antioxidant by selectively reducing cytotoxic oxygen radicals

“Hydrogen selectively reduces the hydroxyl radical, the most toxic free radical, and effectively protects cells. It does not react with free radicals that have physiological benefits, making it an incredibly effective therapy to neutralize acute oxidative stress.”

 

Ohsawa, I., Ishikawa, M., Takahashi, K., Watanabe, M., Nishimaki, K., Yamagata, K., . . . Ohta, S. (2007). Hydrogen acts as a therapeutic antioxidant by selectively reducing cytotoxic oxygen radicals. Nature Medicine, 13(6), 688-694. doi: 10.1038/nm1577

 

​​Consumption of hydrogen water prevents atherosclerosis in apolipoprotein E knockout mice

 

“Atherosclerotic lesions were significantly reduced by ad libitum drinking of H2–water (p = 0.0069) as judged by Oil-Red-O staining series of sections of aorta. The oxidative stress level of aorta was decreased. Accumulation of macrophages in atherosclerotic lesions was confirmed. Thus, consumption of H2-dissolved water has the potential to prevent arteriosclerosis.”

 

Ohsawa, I., Nishimaki, K., Yamagata, K., Ishikawa, M., & Ohta, S. (2008). Consumption of hydrogen water prevents atherosclerosis in apolipoprotein E knockout mice. Biochemical and Biophysical Research Communications, 377(4), 1195-1198. doi: 10.1016/j.bbrc.2008.10.156 

 

​Recent progress toward hydrogen medicine: Potential of molecular hydrogen for preventive and therapeutic applications

“H2 prevented the decline of the mitochondrial membrane potential. This suggested that H2 protected mitochondria from OH. Along with this protective effect, H2 also prevented a decrease in the cellular level of ATP synthesized in mitochondria. The fact that H2 protected mitochondria and nuclear DNA provided evidence that H2 penetrated most membranes and diffused into organelles.”

 

Ohta, S. (2011). Recent progress toward hydrogen medicine: Potential of molecular hydrogen for preventive and therapeutic applications. Current Pharmaceutical Design, 17(22), 2241-2252. doi: 10.2174/138161211797052664 

 

​Hydrogen-rich water decreases serum LDL-cholesterol levels and improves HDL function in patients with potential metabolic syndrome

 

“Supplementation with H2-rich water seems to decrease serum LDL-C and apoB levels, improve dyslipidemia-injured HDL functions, and reduce oxidative stress, and it may have a beneficial role in prevention of potential metabolic syndrome.”

 

Song, G., Li, M., Sang, H., Zhang, L., Li, X., Yao, S., . . . Qin, S. (2013). Hydrogen-rich water decreases serum LDL-cholesterol levels and improves HDL function in patients with potential metabolic syndrome. Journal of Lipid Research, 54(7), 1884-1893. doi: 10.1194/jlr.M036640

 

​Hydrogen-rich saline attenuates lipopolysaccharide-induced heart dysfunction by restoring fatty acid oxidation in rats by mitigating C-jun N-terminal kinase activation

 

“Inhibition of c-Jun N-terminal kinase by Hydrogen-rich saline showed beneficial effects on lipopolysaccharide-challenged rats, at least in part, by restoring cardiac fatty acid oxidation.”

 

Tao, B., Liu, L., Wang, N., Tong, D., Wang, W., & Zhang, J. (2015). Hydrogen-rich saline attenuates lipopolysaccharide-induced heart dysfunction by restoring fatty acid oxidation in rats by mitigating C-jun N-terminal kinase activation. Shock, 44(6), 593-600. doi: 10.1097/SHK.0000000000000467

 

​Hydrogen improves neurological function through attenuation of blood–brain barrier disruption in spontaneously hypertensive stroke-prone rats

 

“The present study suggests that ingestion of Hydrogen-Rich Water can improve neurological function outcome in the spontaneously hypertensive stroke-prone rat model. This beneficial effect may be due to attenuation of BBB disruption via reduction in reactive oxygen species and suppression of matrix metalloproteinases-9 activity in the hippocampus.”

 

Takeuchi, S., Nagatani, K., Otani, N., Nawashiro, H., Sugawara, T., Wada, K., & Mori, K. (2015). Hydrogen improves neurological function through attenuation of blood–brain barrier disruption in spontaneously hypertensive stroke-prone rats. BioMed Central Neuroscience, 16(22), 1-13. doi: 10.1186/s12868-015-0165-3

 

Hydrogen-containing saline attenuates doxorubicin-induced heart failure in rats

 

“Cardiac function was significantly improved and that the plasma levels of oxidative-stress markers and myocardial autophagic activity were decreased in animals treated with hydrogen-containing saline. Therefore, we conclude that hydrogen-containing saline may have beneficial effects for doxorubicin-induced heart failure.”

Wu, S., Zhu, L., Yang, J., Fan, Z., Dong, Y., Luan, R., . .  . Fu, L. (2014). Hydrogen-containing saline attenuates doxorubicin-induced heart failure in rats. Pharmazie, 69(8), 633-636. doi: 10.1691/ph.2014.3859

A review of hydrogen as a new medical therapy

 

“In the past few years many initial and subsequent clinical studies have demonstrated that hydrogen can act as an important physiological regulatory factor to cells and organs on the antioxidant, anti-inflammatory, anti-apoptotic and other protective effects. So far several delivery methods applied in these studies have proved to be available and convenient, including inhalation, drinking hydrogen-dissolved water and injection with hydrogen-saturated saline.”

 

Zhang, J., Liu, C., Zhou, L., Qu, K., Wang, R., Tai, M., . . . Wang, Z. (2012). A Review of hydrogen as a new medical therapy. Hepatogastroenterology, 59(116), 1026-1032. doi: 10.5754/hge11883

 

​Protective effects of hydrogen-rich saline on monocrotaline-induced pulmonary hypertension in a rat model

 

“These results suggest that hydrogen-rich saline ameliorates the progression of pulmonary hypertension induced by monocrotaline in rats, which may be associated with its antioxidant and anti-inflammatory effects.”

 

Wang, Y., Jing, L., Zhao, X., Han, J., Xia, Z., Qin, S., . . . Sun, X. (2011). Protective effects of hydrogen-rich saline on monocrotaline-induced pulmonary hypertension in a rat model. Respiratory Research, 12(26), 1-8. doi: 10.1186/1465-9921-12-26

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