Chronic Disease Prevention and Reversal Program
Research & Studies

Alzheimer’s 

 

“Treatment with H2 appears to elevate brain-derived neurotropic factor, improving brain function. H2 treatment has also been shown to block pathological expression of tau proteins (i.e. neurofibrillary tangles, which are a central feature of Alzheimer's disease). Additionally, H2 appears to combat neuroinflammation and oxidative stress.” 

 

Dohi, K., Kraemer, B. C., Erickson, M. A., Mcmillan, P. J., Kovac, A., Flachbartova, Z., . . . Banks, W. A. (2014). Molecular hydrogen in drinking water protects against neurodegenerative changes induced by traumatic brain injury. PLOS ONE, 9(9), 1-16. doi: 10.1371/journal.pone.0108034

Hong, Y., Chen, S., & Zhang, J. (2010). Hydrogen as a selective antioxidant: A review of clinical and experimental studies. Journal of International Medicine Research, 38(6), 1893-1903. doi: 10.1177/147323001003800602​

 

Li, J., Wang, C., Zhang, J. H., Cai, J., Cao, Y., & Sun, X. (2010). Hydrogen-rich saline improves memory function in a rat model of amyloid-beta-induced Alzheimer's disease by reduction of oxidative stress. Brain Research, 1328, 152-161. doi: 10.1016/j.brainres.2010.02.046

 

Ohsawa, I., Ishikawa, M., Takahashi, K., Watanabe, M., Nishimaki, K., Yamagata, K., . . . Ohta, S. (2007). Hydrogen acts as a therapeutic antioxidant by selectively reducing cytotoxic oxygen radicals. Nature Medicine, 13(6), 688-694. doi: 10.1038/nm1577

 

Chen, C., Chen, Q., Mao, Y., Xu, S., Xia, C., Shi, X., . . . Sun, X. (2010). Hydrogen-rich saline protects against spinal cord injury in rats. Neurochemical Research, 35(7), 1111-1118. doi: 10.1007/s11064-010-0162-y

 

Feng, Y., Wang, R., Xu, J., Sun, J., Xu, T., Gu, Q., & Wu, X. (2012). Hydrogen-rich saline prevents early neurovascular dysfunction resulting from inhibition of oxidative stress in STZ-diabetic rats. Current Eye Research, 38(3), 396-404. doi: 10.3109/02713683.2012.748919

 

Wang, C., Li, J., Liu, Q., Yang, R., Zhang, J. H., Cao, Y., & Sun, X. (2011). Hydrogen-rich saline reduces oxidative stress and inflammation by inhibit of JNK and NF-κB activation in a rat model of amyloid-beta-induced Alzheimer's disease. Neuroscience Letters, 491(2), 127-132. doi: 10.1016/j.neulet.2011.01.022

 

Lin, C., Huang, W., Li, H., Huang, C., Hsieh, S., Lai, C., & Lu, F. (2015). Hydrogen-rich water attenuates amyloid β-induced cytotoxicity through upregulation of Sirt1-FoxO3a by stimulation of AMP-activated protein kinase in SK-N-MC cells. Chemico-Biological Interactions, 240, 12-21. doi: 10.1016/j.cbi.2015.07.013

 

 

Autoimmune Diseases 

 

“In addition to the apparent beneficial applications for rheumatoid arthritis, the powerful antioxidant and anti-inflammatory ability of H2 would logically promote a healthy immune balance.”

 

Ishibashi, T., Sato, B., Rikitake, M., Seo, T., Kurokawa, R., Hara, Y., . . . Nagao, T. (2012). Consumption of water containing a high concentration of molecular hydrogen reduces oxidative stress and disease activity in patients with rheumatoid arthritis: An open-label pilot study. Medical Gas Research, 2(27), 1-8. doi: 10.1186/2045-9912-2-27

 

Ishibashi, T., Sato, B., Shibata, S., Sakai, T., Hara, Y., Naritomi, Y., . . . Nagao, T. (2014). Therapeutic efficacy of infused molecular hydrogen in saline on rheumatoid arthritis: A randomized, double-blind, placebo-controlled pilot study. International Immunopharmacology, 21(2), 468-473. doi: 10.1016/j.intimp.2014.06.001

 

Meng, J., Yu, P., Jiang, H., Yuan, T., Liu, N., Tong, J., . . . Zhao, J. (2016). Molecular hydrogen decelerates rheumatoid arthritis progression through inhibition of oxidative stress. American Journal of Translational Research, 8(10), 4472-4477. Retrieved from https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5095341/

 

Zhao, M., Liu, M., Pu, Y., Wang, D., Xie, Y., Xue, G., . . . Cao, L. (2016). Hydrogen-rich water improves neurological functional recovery in experimental autoimmune encephalomyelitis mice. Journal of Neuroimmunology, 294, 6-13. doi: 10.1016/j.jneuroim.2016.03.006

 

Ishibashi, T. (2013). Molecular hydrogen: New antioxidant and anti-inflammatory therapy for rheumatoid arthritis and related diseases. Current Pharmaceutical Design, 19(35), 6375-6381. doi: 10.2174/13816128113199990507

Cancer 

 

“H2 prevents oxidative stress and regulates gene expression and also alleged symptoms from radiation therapy. H2 has also been shown to halt tumor growth and convert cancer cells back to normal cells due to its selective free radical scavenging ability. Significant benefits have been demonstrated for a number of different cancers, including liver, tongue, and colon cancer.”

 

Hong, Y., Chen, S., & Zhang, J. (2010). Hydrogen as a selective antioxidant: A review of clinical and experimental studies. Journal of International Medical Research, 38(6), 1893-1903. doi: 10.1177/147323001003800602

 

Kang, KM., Kang, YM., et al. (2011). Effects of drinking hydrogen-rich water on the quality of life of patients treated with radiotherapy for liver tumors. Medical Gas Research, 1(11), 1-8. doi: 10.1186/2045-9912-1-11

 

Ohno, K., Ito, M., Ichihara, M., & Ito, M. (2012). Molecular hydrogen as an emerging therapeutic medical gas for neurodegenerative and other diseases. Oxidative Medicine and Cellular Longevity, 2012(353152), 1-11. doi: 10.1155/2012/353152

 

Ohsawa, I., Ishikawa, M., Takahashi, K., Watanabe, M., Nishimaki, K., Yamagata, K., . . . Ohta, S. (2007). Hydrogen acts as a therapeutic antioxidant by selectively reducing cytotoxic oxygen radicals. Nature Medicine, 13(6), 688-694. doi: 10.1038/nm1577

 

Ohta, S. (2011). Recent progress toward hydrogen medicine: Potential of molecular hydrogen for preventive and therapeutic applications. Current Pharmaceutical Design, 17(22), 2241-2252. doi: 10.2174/138161211797052664

 

Saitoh, Y., Yoshimura, Y., Nakano, K., Miwa, N. (2009). Platinum nanocolloid-supplemented hydrogen dissolved water inhibits growth of human tongue carcinoma cells preferentially over normal cells. Experimental Oncology, 31(3), 156-162. Retrieved from http://exp-oncology.com.ua/uploads/magazine/772.pdf?upload 

 

Saitoh, Y., Okayasu, H., Xiao, L., Harata, Y., & Miwa, N. (2008). Neutral pH hydrogen-enriched electrolyzed water achieves tumor-preferential clonal growth inhibition over normal cells and tumor invasion inhibition concurrently with intracellular oxidant repression. Oncology Research Featuring Preclinical and Clinical Cancer Therapeutics, 17(6), 247-255. doi: 10.3727/096504008786991620

 

Runtuwene, J., Amitani, H., Amitani, M., Asakawa, A., Cheng, K., & Inui, A. (2015). Hydrogen–water enhances 5-fluorouracil-induced inhibition of colon cancer. PeerJ, 3, 1-15. doi: 10.7717/peerj.859 

 

Nakanishi, K., Hamasaki, T., Nakamura, T., Abe, M., Teruya, K., Katakura, Y., . . . Shirahata, S. (2010). Growth Suppression of HL60 and L6 Cells by Atomic Hydrogen. Animal Cell Technology: Basic and Applied Aspects, 16, 323-325. doi: 10.1007/978-90-481-3892-0_53

 

Cirrhosis 

 

“Multiple studies on mice and rats have shown that H2 can repair liver damage and reduce inflammation associated with liver disease. H2 was shown to suppress liver fibrosis, which is a universal consequence of chronic liver disease. In other studies, H2 relieved liver injury, mostly because of its abilities to activate the body's antioxidant capabilities and to down regulate extracellular signal-regulated protein kinase activation.” 

 

Koyama, Y., Taura, K., Hatano, E., Tanabe, K., Yamamoto, G., Nakamura, K., . . . Uemoto, S. (2013). Effects of oral intake of hydrogen water on liver fibrogenesis in mice. Hepatology Research, 44(6), 663-677. doi: 10.1111/hepr.12165

 

Liu, Q., Shen, W., Sun, H., Fan, D., Nakao, A., Cai, J., . . . Sun, X. (2010). Hydrogen-rich saline protects against liver injury in rats with obstructive jaundice. Liver International, 30(7), 958-968. doi: 10.1111/j.1478-3231.2010.02254.x

 

Sun, H., Chen, L., Zhou, W., Hu, L., Li, L., Tu, Q., . . . Wang, H. (2011). The protective role of hydrogen-rich saline in experimental liver injury in mice. Journal of Hepatology, 54(3), 471-480. doi: 10.1016/j.jhep.2010.08.011

 

Lee, P., Yang, Y., Huang, C., Hsieh, S., Lee, K., Hsieh, Y., . . . Lin, H. (2014). Concomitant inhibition of oxidative stress and angiogenesis by chronic hydrogen-rich saline and N-acetylcysteine treatments improves systemic, splanchnic and hepatic hemodynamics of cirrhotic rats. Hepatology Research, 45(5), 578-588. doi: 10.1111/hepr.12379

 

Colitis 

 

“In a study on rats with ulcerative colitis, treatment with H2 water alleviated mucosal damage of the colon and reduced diarrhea and weight loss. Additionally, H2 may inhibit vascular endothelial growth factor (VEGF), which is correlated with disease activity.”

 

He, J., Xiong, S., Zhang, J., Wang, J., Sun, A., Mei, X., . . . Wang, Q. (2013). Protective effects of hydrogen-rich saline on ulcerative colitis rat model. Journal of Surgical Research, 185(1), 174-181. doi: 10.1016/j.jss.2013.05.047

 

Sheng, Q., Lv, Z., Cai, W., Song, H., Qian, L., & Wang, X. (2013). Protective effects of hydrogen-rich saline on necrotizing enterocolitis in neonatal rats. Journal of Pediatric Surgery, 48(8), 1697-1706. doi: 10.1016/j.jpedsurg.2012.11.038

 

Kajiya, M., Silva, M. J., Sato, K., Ouhara, K., & Kawai, T. (2009). Hydrogen mediates suppression of colon inflammation induced by dextran sodium sulfate. Biochemical and Biophysical Research Communications, 386(1), 11-15. doi: 10.1016/j.bbrc.2009.05.117

 

CTE

 

“A variety of studies shown strong potential for H2 to be a highly effective and easily administered treatment of traumatic brain injury and concussion, and potentially in cases of CTE.  In one study, a treatment with H2 water reduced the acute changes induced controlled cortical impact (CCI) by about half and completely blocked pathological tau expression.”

 

Dohi, K., Kraemer, B. C., Erickson, M. A., Mcmillan, P. J., Kovac, A., Flachbartova, Z., . . . Banks, W. A. (2014). Molecular hydrogen in drinking water protects against neurodegenerative changes induced by traumatic brain injury. PLOS ONE, 9(9), 1-16. doi: 10.1371/journal.pone.0108034

 

Hou, Z., Luo, W., Sun, X., Hao, S., Zhang, Y., Xu, F., . . . Liu, B. (2012). Hydrogen-rich saline protects against oxidative damage and cognitive deficits after mild traumatic brain injury. Brain Research Bulletin, 88(6), 560-565. doi: 10.1016/j.brainresbull.2012.06.006

 

Ji, X., Liu, W., Xie, K., Liu, W., Qu, Y., Chao, X., . . . Fei, Z. (2010). Beneficial effects of hydrogen gas in a rat model of traumatic brain injury via reducing oxidative stress. Brain Research, 1354, 196-205. doi: 10.1016/j.brainres.2010.07.03

 

Ohsawa, I., Ishikawa, M., Takahashi, K., Watanabe, M., Nishimaki, K., Yamagata, K., . . . Ohta, S. (2007). Hydrogen acts as a therapeutic antioxidant by selectively reducing cytotoxic oxygen radicals. Nature Medicine, 13(6), 688-694. doi: 10.1038/nm1577

 

Zhuang, Z., Zhou, M., You, W., Zhu, L., Ma, C., Sun, X., & Shi, J. (2012). Hydrogen-rich saline alleviates early brain injury via reducing oxidative stress and brain edema following experimental subarachnoid hemorrhage in rabbits. BioMed Central Neuroscience, 13(47), 1-10. doi: 10.1186/1471-2202-13-47

 

 

Dementia 

 

“Treatment with H2 appears to elevate brain-derived neurotropic factor, improving brain function. H2 treatment has also been shown to block pathological expression of tau proteins (i.e. neurofibrillary tangles, which are a central feature of dementia and Alzheimer's disease). Additionally, H2 appears to combat neuroinflammation and oxidative stress.”

 

Li, J., Wang, C., Zhang, J. H., Cai, J., Cao, Y., & Sun, X. (2010). Hydrogen-rich saline improves memory function in a rat model of amyloid-beta-induced Alzheimer's disease by reduction of oxidative stress. Brain Research, 1328, 152-161. doi: 10.1016/j.brainres.2010.02.046

 

Chen, C., Chen, Q., Mao, Y., Xu, S., Xia, C., Shi, X., . . . Sun, X. (2010). Hydrogen-rich saline protects against spinal cord injury in rats. Neurochemical Research, 35(7), 1111-1118. doi: 10.1007/s11064-010-0162-y

 

Ohsawa, I., Ishikawa, M., Takahashi, K., Watanabe, M., Nishimaki, K., Yamagata, K., . . . Ohta, S. (2007). Hydrogen acts as a therapeutic antioxidant by selectively reducing cytotoxic oxygen radicals. Nature Medicine, 13(6), 688-694. doi: 10.1038/nm1577

 

Feng, Y., Wang, R., Xu, J., Sun, J., Xu, T., Gu, Q., & Wu, X. (2012). Hydrogen-rich saline prevents early neurovascular dysfunction resulting from inhibition of oxidative stress in STZ-diabetic rats. Current Eye Research, 38(3), 396-404. doi: c10.3109/02713683.2012.748919

 

Wang, C., Li, J., Liu, Q., Yang, R., Zhang, J. H., Cao, Y., & Sun, X. (2011). Hydrogen-rich saline reduces oxidative stress and inflammation by inhibit of JNK and NF-κB activation in a rat model of amyloid-beta-induced Alzheimer's disease. Neuroscience Letters, 491(2), 127-132. doi: 10.1016/j.neulet.2011.01.022

 

Lin, C., Huang, W., Li, H., Huang, C., Hsieh, S., Lai, C., & Lu, F. (2015). Hydrogen-rich water attenuates amyloid β-induced cytotoxicity through upregulation of Sirt1-FoxO3a by stimulation of AMP-activated protein kinase in SK-N-MC cells. Chemico-Biological Interactions, 240, 12-21. doi: 10.1016/j.cbi.2015.07.013

 

 

 

Diabetes 

 

“Oxidative stress is widely recognized as being associated with a number of diseases, including type 2 diabetes. In a randomized, double-blind, placebo-controlled study on patients with either type 2 diabetes or impaired glucose tolerance, treatment with H2 rich water was associated with significant improvements in lipid and glucose metabolism, suggesting that hydrogen-rich water may have a beneficial role in the prevention of type 2 diabetes and insulin resistance.”

 

Kajiyama, S., Hasegawa, G., Asano, M., Hosoda, H., Fukui, M., Nakamura, N., . . . Yoshikawa, T. (2008). Supplementation of hydrogen-rich water improves lipid and glucose metabolism in patients with type 2 diabetes or impaired glucose tolerance. Nutrition Research, 28(3), 137-143. doi: 10.1016/j.nutres.2008.01.008 

 

Amitani, H., Asakawa, A., Cheng, K., Amitani, M., Kaimoto, K., Nakano, M., . . . Inui, A. (2013). Hydrogen improves glycemic control in type1 diabetic animal model by promoting glucose uptake into skeletal muscle. PLOS ONE, 8(1), 1-14. doi: 10.1371/journal.pone.0053913

 

Li, Y., Hamasaki, T., Nakamichi, N., Kashiwagi, T., Komatsu, T., Ye, J., . . . Shirahata, S. (2010). Suppressive effects of electrolyzed reduced water on alloxan-induced apoptosis and type 1 diabetes mellitus. Cytotechnology, 63(2), 119-131. doi: 10.1007/s10616-010-9317-6

 

Kamimura, N., Nishimaki, K., Ohsawa, I., & Ohta, S. (2011). Molecular hydrogen improves obesity and diabetes by inducing hepatic FGF21 and stimulating energy metabolism in db/db mice. Obesity, 19(7), 1396-1403. doi: 10.1038/oby.2011.6

 

Gu, Y., Oonishi, K., Fujii, T., Itokawa, Y., Masubuchi, T., Kurono, Y., . . . Ishida, T. (2006). Anti type 2 diabetic effect and anti-oxidation effect in active hydrogen water administration KK-Ay mice. Medicine and Biology, 150(11), 384-392. Retrieved from http://www.suzuka-u.ac.jp/information/bulletin/pdf/07-02-gu2.pdf ​

 

Katakura, M., Hashimoto, M., Tanabe, Y., & Shido, O. (2012). Hydrogen-rich water inhibits glucose and α,β -dicarbonyl compound-induced reactive oxygen species production in the SHR.Cg-Leprcp/NDmcr rat kidney. Medical Gas Research, 2(18), 1-7. doi: 10.1186/2045-9912-2-18

 

Heart Disease/Cardiovascular Health

 

“H2 has been shown to stop fatty deposits in the blood vessels of the heart in studies involving rats. H2 also was shown to significantly reduce atherosclerotic lesions and decrease oxidative stress.”

 

Cistulli, P. A., & Phillips, C. L. (2010). Expanding the clinical spectrum of OSA – An association with pulmonary embolism? Sleep, 33(8), 1009–1010. Retrieved from https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2910530/

​​

Dixon, B. J., Tang, J., & Zhang, J. H. (2013). The evolution of molecular hydrogen: A noteworthy potential therapy with clinical significance. Medical Gas Research, 3(10), 1-12. doi: 10.1186/2045-9912-3-10

 

Dong, T., Cheng, Y., Yang, F., Sun, P., Zhu, C., Zhu, L., & Zhang, G. (2015). Chronic stress facilitates the development of deep venous thrombosis. Oxidative Medicine and Cellular Longevity, 2015, 1-8. doi: 10.1155/2015/384535

Ekuni, D., Tomofuji, T., Endo, Y., Kasuyama, K., Irie, K., Azuma, T., . . . Morita, M. (2012). Hydrogen-rich water prevents lipid deposition in the descending aorta in a rat periodontitis model. Archives of Oral Biology, 57(12), 1615-1622. doi: 10.1016/j.archoralbio.2012.04.013

 

Esmon, C. (2003, June 20). Inflammation and thrombosis. Journal of Thrombosis and Haemostasis, 1(7), 1343-1348. doi: 10.1046/j.1538-7836.2003.00261.x

Freedman, J. E., & Loscalzo, J. (2003). Nitric oxide and its relationship to thrombotic disorders. Journal of Thrombosis and Haemostasis, 1(6), 1183-1188. doi: 10.1046/j.1538-7836.2003.00180.x

Hayashi, T., Yoshioka, T., Hasegawa, K., Miyamura, M., Mori, T., Ukimura, A., . . . Ishizaka, N. (2011). Inhalation of hydrogen gas attenuates left ventricular remodeling induced by intermittent hypoxia in mice. American Journal of Physiology: Heart and Circulatory Physiology, 301(3), 1062-1069. doi: 10.1152/ajpheart.00150.2011 

 

Hong, Y., Chen, S., & Zhang, J. (2010). Hydrogen as a selective antioxidant: A review of clinical and experimental studies. Journal of International Medical Research, 38(6), 1893-1903. doi: 10.1177/147323001003800602

 

Huo, T., Zeng, Y., Liu, X., Sun, L., Han, H., Chen, H., . . . Xiong, L. (2014). Hydrogen-rich saline improves survival and neurological outcome after cardiac arrest and cardiopulmonary resuscitation in rats. Anesthesia & Analgesia, 119(2), 368-380. doi: 10.1213/ane.0000000000000303 

 

Jin, R. C., Mahoney, C. E., Anderson, L. (Coleman), Ottaviano, F., Croce, K., Leopold, J. A., … Loscalzo, J. (2011). Glutathione peroxidase-3 deficiency promotes platelet-dependent thrombosis in vivo. Circulation, 123(18), 1963–1973. doi: 10.1161/CIRCULATIONAHA.110.000034

 

Noda, K., Tanaka, Y., Shigemura, N., Kawamura, T., Wang, Y., Masutani, K., . . . Nakao, A. (2012). Hydrogen-supplemented drinking water protects cardiac allografts from inflammation-associated deterioration. Transplant International, 25(12), 1213-1222. doi: 10.1111/j.1432-2277.2012.01542.x 

 

Ohsawa, I., Ishikawa, M., Takahashi, K., Watanabe, M., Nishimaki, K., Yamagata, K., . . . Ohta, S. (2007). Hydrogen acts as a therapeutic antioxidant by selectively reducing cytotoxic oxygen radicals. Nature Medicine, 13(6), 688-694. doi: 10.1038/nm1577

Ohsawa, I., Nishimaki, K., Yamagata, K., Ishikawa, M., & Ohta, S. (2008). Consumption of hydrogen water prevents atherosclerosis in apolipoprotein E knockout mice. Biochemical and Biophysical Research Communications, 377(4), 1195-1198. doi: 10.1016/j.bbrc.2008.10.156 

 

Ohta, S. (2011). Recent progress toward hydrogen medicine: Potential of molecular hydrogen for preventive and therapeutic applications. Current Pharmaceutical Design, 17(22), 2241-2252. doi: 10.2174/138161211797052664 

 

Poredos, P., & Jezovnik, M. (2007, December). The role of inflammation in venous thromboembolism and the link between arterial and venous thrombosis. International Angiology, 26(4), 306-311.​​ Retrieved from https://www.ncbi.nlm.nih.gov/pubmed/18091697

Re, G., Lanzarini, C., Vaona, I., Pazzaglia, M., Palareti, G., Bassein, L., & Guarnieri, C. (1998). Systemically circulating oxidative species in human deep venous thrombosis. European Journal of Emergency Medicine, 5(1), 9-12. doi: 10.1097/00063110-199803000-00004

Reguig, S. B., Bouanane, S., Merzouk, H., Soufi, N. & Merzouk, S. A. (2016) Oxidative stress and thrombotic disorders: study in patients with venous thromboembolism. International Journal of Health Sciences and Research, 6(1), 185-194. Retrieved from http://www.scopemed.org/?mno=214288#cite

 

Fan, M., Xu, X., He, X., Chen, L., Qian, L., Liu, J., . . . Sun, X. (2013). Protective effects of hydrogen-rich saline against erectile dysfunction in a streptozotocin induced diabetic rat model. The Journal of Urology, 190(1), 350-356. doi: 10.1016/j.juro.2012.12.001

Song, G., Li, M., Sang, H., Zhang, L., Li, X., Yao, S., . . . Qin, S. (2013). Hydrogen-rich water decreases serum LDL-cholesterol levels and improves HDL function in patients with potential metabolic syndrome. Journal of Lipid Research, 54(7), 1884-1893. doi: 10.1194/jlr.M036640

 

Tao, B., Liu, L., Wang, N., Tong, D., Wang, W., & Zhang, J. (2015). Hydrogen-rich saline attenuates lipopolysaccharide-induced heart dysfunction by restoring fatty acid oxidation in rats by mitigating C-jun N-terminal kinase activation. Shock, 44(6), 593-600. doi: 10.1097/SHK.0000000000000467

 

Takeuchi, S., Nagatani, K., Otani, N., Nawashiro, H., Sugawara, T., Wada, K., & Mori, K. (2015). Hydrogen improves neurological function through attenuation of blood–brain barrier disruption in spontaneously hypertensive stroke-prone rats. BioMed Central Neuroscience, 16(22), 1-13. doi: 10.1186/s12868-015-0165-3

 

Wakefield, T. W., & Henke, P. K. (2005). The role of inflammation in early and late venous thrombosis: Are there clinical implications? Seminars in Vascular Surgery, 18(3), 118-129. doi: 10.1053/j.semvascsurg.2005.05.003

Wang, C., Yang, F., Xu, Z., Shi, D., Chen, D., Dai, J., . . . Jiang, Q. (2013). Intravenous release of NO from lipidic microbubbles accelerates deep vein thrombosis resolution in a rat model. Thrombosis Research, 131(1), 31-38. doi: 10.1016/j.thromres.2012.11.002

Wu, S., Zhu, L., Yang, J., Fan, Z., Dong, Y., Luan, R., . .  . Fu, L. (2014). Hydrogen-containing saline attenuates doxorubicin-induced heart failure in rats. Pharmazie, 69(8), 633-636. doi: 10.1691/ph.2014.3859

 

Zhang, J., Liu, C., Zhou, L., Qu, K., Wang, R., Tai, M., . . . Wang, Z. (2012). A Review of hydrogen as a new medical therapy. Hepatogastroenterology, 59(116), 1026-1032. doi: 10.5754/hge11883

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