Diabetes Program
Research & Studies

Hydrogen improves glycemic control in type1 diabetic animal model by promoting glucose uptake into skeletal muscle

 

“Our study demonstrates that H(2) exerts metabolic effects similar to those of insulin and may be a novel therapeutic alternative to insulin in type 1 diabetes mellitus that can be administered orally.”

 

Amitani, H., Asakawa, A., Cheng, K., Amitani, M., Kaimoto, K., Nakano, M., . . . Inui, A. (2013). Hydrogen improves glycemic control in type1 diabetic animal model by promoting glucose uptake into skeletal muscle. PLOS ONE, 8(4), 1-14. doi: 10.1371/journal.pone.0053913

 

The evolution of molecular hydrogen:  A noteworthy potential therapy with clinical significance

 

“There have been quite a few studies involving molecular hydrogen directly as a treatment for the various conditions and secondary complications that comprise or are caused by diabetes mellitus. The studies indicate that hydrogen maybe a novel therapy to diabetic complications and have a possible therapeutic role in diabetes mellitus itself.”

 

Dixon, B. J., Tang, J., & Zhang, J. H. (2013). The evolution of molecular hydrogen: A noteworthy potential therapy with clinical significance. Medical Gas Research, 3(10), 1-12. doi: 10.1186/2045-9912-3-10

Hydrogen-rich saline prevents early neurovascular dysfunction resulting from inhibition of oxidative stress in STZ-diabetic rats

 

“Based on its inhibition of oxidative stress and up-regulation of anti-oxidative enzymes, we conclude that hydrogen-rich saline is a potentially valuable therapeutic modality for the treatment of Diabetic Retinopathy.”

 

Feng, Y., Wang, R., Xu, J., Sun, J., Xu, T., Gu, Q., & Wu, X. (2012). Hydrogen-rich saline prevents early neurovascular dysfunction resulting from inhibition of oxidative stress in STZ-diabetic rats. Current Eye Research, 38(3), 396-404. doi: 10.3109/02713683.2012.748919

 

Anti type 2 diabetic effect and anti-oxidation effect in active hydrogen water administration KK-Ay mice

 

“Active hydrogen water is capable of anti-oxidation and it also has a controlling effect on the blood glucose level in type 2 diabetes.”

 

Gu, Y., Oonishi, K., Fujii, T., Itokawa, Y., Masubuchi, T., Kurono, Y., . . . Ishida, T. (2006). Anti type 2 diabetic effect and anti-oxidation effect in active hydrogen water administration KK-Ay mice. Medicine and Biology, 150(11), 384-392. Retrieved from http://www.suzuka-u.ac.jp/information/bulletin/pdf/07-02-gu2.pdf ​

 

Molecular hydrogen attenuates fatty acid uptake and lipid accumulation through downregulating CD36 expression in HepG2 cells

 

“Hydrogen inhibits fatty acid uptake and lipid accumulation through the downregulation of CD36 at the protein level in hepatic cultured cells, providing insights into the molecular mechanism underlying the hydrogen effects in vivo on lipid metabolism disorders.”

 

Iio, A., Ito, M., Itoh, T., Terazawa, R., Fujita, Y., Nozawa, Y., . . . Ito, M. (2013). Molecular hydrogen attenuates fatty acid uptake and lipid accumulation through downregulating CD36 expression in HepG2 cells. Medical Gas Research, 3(6), 1-7. doi: 10.1186/2045-9912-3-6

 

 

Therapeutic effects of hydrogen saturated saline on rat diabetic model and insulin resistant model via reduction of oxidative stress

 

“Hydrogen saturated saline showed great efficiency in improving the insulin sensitivity and lowering blood glucose and lipids. Hydrogen saturated saline markedly attenuated the malondialdehyde level and elevated the levels of antioxidants superoxide dismutase and glutathione.”

 

Wang, Q., Zha, X., Kang, Z., Xu, M., Huang, Q., & Zou, D. (2012). Therapeutic effects of hydrogen saturated saline on rat diabetic model and insulin resistant model via reduction of oxidative stress. Chinese Medical Journal, 125(9), 1633-1637. Retrieved from https://www.ncbi.nlm.nih.gov/pubmed/22800834

 

Supplementation of hydrogen-rich water improves lipid and glucose metabolism in patients with type 2 diabetes or impaired glucose tolerance

 

“In 4 of 6 patients with impaired glucose tolerance, intake of hydrogen-rich water normalized the oral glucose tolerance test. In conclusion, these results suggest that supplementation with hydrogen-rich water may have a beneficial role in prevention of T2DM and insulin resistance.”

 

Kajiyama, S., Hasegawa, G., Asano, M., Hosoda, H., Fukui, M., Nakamura, N., . . . Yoshikawa, T. (2008). Supplementation of hydrogen-rich water improves lipid and glucose metabolism in patients with type 2 diabetes or impaired glucose tolerance. Nutrition Research, 28(3), 137-143. doi: 10.1016/j.nutres.2008.01.008 

 

Molecular hydrogen improves obesity and diabetes by inducing hepatic FGF21 and stimulating energy metabolism in db/db mice

 

“Drinking H(2)-water decreased levels of plasma glucose, insulin, and triglyceride, the effect of which on hyperglycemia was similar to diet restriction.”

 

Kamimura, N., Nishimaki, K., Ohsawa, I., & Ohta, S. (2011). Molecular hydrogen improves obesity and diabetes by inducing hepatic FGF21 and stimulating energy metabolism in db/db mice. Obesity, 19(7), 1396-1403. doi: 10.1038/oby.2011.6

 

Hydrogen-rich water inhibits glucose and α,β -dicarbonyl compound-induced reactive oxygen species production in the SHR.Cg-Lepr cp /NDmcr rat kidney

 

“Hydrogen rich water inhibited glucose- and α,β-dicarbonyl compound-induced ROS production in kidney homogenates from Wistar rats in vitro. Therefore, it has therapeutic potential for renal dysfunction in patient with type 2 diabetes and metabolic syndrome.”

 

Katakura, M., Hashimoto, M., Tanabe, Y., & Shido, O. (2012). Hydrogen-rich water inhibits glucose and α,β -dicarbonyl compound-induced reactive oxygen species production in the SHR.Cg-Leprcp/NDmcr rat kidney. Medical Gas Research, 2(18), 1-7. doi: 10.1186/2045-9912-2-18

 

Protective effects of hydrogen-rich saline against erectile dysfunction in a streptozotocin induced diabetic rat model

 

“Hydrogen-rich saline effectively improved erectile function in a streptozotocin induced diabetic rat model of erectile dysfunction.”

 

Fan, M., Xu, X., He, X., Chen, L., Qian, L., Liu, J., . . . Sun, X. (2013). Protective effects of hydrogen-rich saline against erectile dysfunction in a streptozotocin induced diabetic rat model. The Journal of Urology, 190(1), 350-356. doi: 10.1016/j.juro.2012.12.001

 

 

Anti-diabetes effect of water containing hydrogen molecule and Pt nanoparticles

 

“In the groups of H2, Pt NPs and their combined use groups, blood sugar levels and impaired sugar tolerance of type 2 diabetes model mouse (KK-Ay) were significantly improved, suggesting that H2, Pt NPs and H are redox regulation factors in animal cells.”

 

Shirahata, S., Hamasaki, T., Haramaki, K., Nakamura, T., Abe, M., Yan, H., . . . Teruya, K. (2011). Anti-diabetes effect of water containing hydrogen molecule and Pt nanoparticles. BioMed Central Proceedings, 5(8), 1-3. doi: 10.1186/1753-6561-5-s8-p18

 

Protective effects of hydrogen saline on diabetic retinopathy in a streptozotocin-induced diabetic rat model

 

“H2 saline may have potentials in the clinical treatment of diabetic retinopathy.”

 

Xiao, X., Cai, J., Xu, J., Wang, R., Cai, J., Liu, Y., . . . Li, R. (2012). Protective effects of hydrogen saline on diabetic retinopathy in a streptozotocin-induced diabetic rat model. Journal of Ocular Pharmacology and Therapeutics, 28(1), 76-82. doi: 10.1089/jop.2010.0129

Hydrogen-rich medium protects human skin fibroblasts from high glucose or mannitol induced oxidative damage

 

“Hydrogen may have applications in the treatment of skin diseases caused by diabetes.”

 

Yu, P., Wang, Z., Sun, X., Chen, X., Zeng, S., Chen, L., & Li, S. (2011). Hydrogen-rich medium protects human skin fibroblasts from high glucose or mannitol induced oxidative damage. Biochemical and Biophysical Research Communications, 409(2), 350-355. doi: 10.1016/j.bbrc.2011.05.024

 

Diabetes, oxidative stress, and antioxidants: A review

 

“Increasing evidence in both experimental and clinical studies suggests that oxidative stress plays a major role in the pathogenesis of both types of diabetes mellitus. Free radicals are formed disproportionately in diabetes by glucose oxidation, nonenzymatic glycation of proteins, and the subsequent oxidative degradation of glycated proteins. Abnormally high levels of free radicals and the simultaneous decline of antioxidant defense mechanisms can lead to damage of cellular organelles and enzymes, increased lipid peroxidation, and development of insulin resistance.”

 

Maritim, A. C., Sanders, R. A., & Watkins III, J. B. (2003). Diabetes, oxidative stress, and antioxidants: A review. The journal biochemical of molecular toxiclogy, 17(1), 24-38. doi: 10.1002/jbt.10058

 

Hydrogen acts as a therapeutic antioxidant by selectively reducing cytotoxic oxygen radicals

“Hydrogen selectively reduces the hydroxyl radical, the most toxic free radical, and effectively protects cells. It does not react with free radicals that have physiological benefits, making it an incredibly effective therapy to neutralize acute oxidative stress.”

 

Ohsawa, I., Ishikawa, M., Takahashi, K., Watanabe, M., Nishimaki, K., Yamagata, K., . . . Ohta, S. (2007). Hydrogen acts as a therapeutic antioxidant by selectively reducing cytotoxic oxygen radicals. Nature Medicine, 13(6), 688-694. doi: 10.1038/nm1577  

 

Diabetes, oxidative stress and therapeutic strategies

 

“The exact mechanisms underlying the disease are unknown; however, there is growing evidence that excess generation of reactive oxygen species (ROS), largely due to hyperglycemia, causes oxidative stress in a variety of tissues. Oxidative stress results from either an increase in free radical production, or a decrease in endogenous antioxidant defenses, or both. ROS and reactive nitrogen species (RNS) are products of cellular metabolism and are well recognized for their dual role as both deleterious and beneficial species. In type 2 diabetic patients, oxidative stress is closely associated with chronic inflammation.”

 

Rochette, L., Zeller, M., Cottin, Y., & Vergely, C. (2014). Diabetes, oxidative stress and therapeutic strategies. Biochimica et Biophysica acta, 1840(9), 2709-2729. doi: 10.1016/j.bbagen.2014.05.017

 

Hydrogen as a selective antioxidant: A review of clinical and experimental studies

“H2 is emerging as a novel and safe therapeutic antioxidant. It has selective antioxidant properties, giving it anti-inflammatory properties.”

 

Hong, Y., Chen, S., & Zhang, J. (2010). Hydrogen as a selective antioxidant: A review of clinical and experimental studies. Journal of International Medical Research, 38(6), 1893-1903. doi: 10.1177/147323001003800602  

 

Oxidative stress, diabetes, and diabetic complications

 

“Oxidative stress is considered to be the main cause for several chronic diseases including diabetes. Through hyperglycemia, hyperlipidemia, hypertension and possible iron dyshomeostasis, diabetes induces oxidative stress that causes damage to multiple organs, leading to various complications. Therefore, antioxidant therapy may be an interesting approach to prevent diabetes and diabetic complications.”

 

Wei, W., Liu, Q., Tan, Y., Liu, L., Li, X., & Cai, L. (2009). Oxidative stress, diabetes, and diabetic complications. Hemoglobin, 33(5), 370-377. Retrieved from 10.3109/03630260903212175

 

Recent progress toward hydrogen medicine: Potential of molecular hydrogen for preventive and therapeutic applications

 

“H2 has a number of advantages as a potential antioxidant: H2 rapidly diffuses into tissues and cells, and it is mild enough neither to disturb metabolic redox reactions nor to affect reactive oxygen species (ROS) that function in cell signaling, thereby, there should be little adverse effects of consuming H2. H2 shows not only effects against oxidative stress, but also various anti-inflammatory and anti-allergic effects. Moreover, H2 passes through the blood brain barrier, although most antioxidant compounds cannot; this is also an advantage of H2.”

 

Ohta, S. (2011). Recent progress toward hydrogen medicine: Potential of molecular hydrogen for preventative and therapeutic applications. Current Pharmaceutical Design, 17(22), 2241-2252. doi: 10.2174/138161211797052664

 

Oxidative stress, insulin resistance, dyslipidemia and type 2 diabetes mellitus

 

“Oxidative stress is increased in metabolic syndrome and type 2 diabetes mellitus (T2DM) and this appears to underlie the development of cardiovascular disease, T2DM and diabetic complications. Increased oxidative stress appears to be a deleterious factor leading to insulin resistance, dyslipidemia, β-cell dysfunction, impaired glucose tolerance and ultimately leading to T2DM.”

 

Tangvarasittichai, S. (2015). Oxidative stress, insulin resistance, dyslipidemia and type 2 diabetes mellitus. World Journal of Diabetes, 6(3), 456-480. doi: 10.4239/wjd.v6.i3.456

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