Migraines

Research & Studies

Oxidative stress is associated with migraine and migraine-related metabolic risk in females

 

“We show here that increased oxidative stress is associated with migraine and contributes to migraine-related metabolic risk like nitrosative stress, an atherogenic lipid profile and hyperinsulinemia. Our data suggest that oxidative stress may represent a key event in the pathophysiology of migraine and a suitable therapeutic target.”

 

Bernecker, C., Ragginer, C., Fauler, G., Horejsi, R., Möller, R., Zelzer, S., . . . Gruber, H. (2011). Oxidative stress is associated with migraine and migraine-related metabolic risk in females. European Journal of Neurology, 18(10), 1233-1239. doi: 10.1111/j.1468-1331.2011.03414.x

 

The evolution of molecular hydrogen: A noteworthy potential therapy with clinical significance

 

“Hydrogen is qualified to cross the blood brain barrier, to enter the mitochondria, and even has the ability to translocate to the nucleus under certain conditions. Once in these ideal locations of the cell, previous studies have shown that hydrogen exerts antioxidant, anti-apoptotic, anti-inflammatory, and cytoprotective properties that are beneficial to the cell.”

 

Dixon, B. J., Tang, J., & Zhang, J. H. (2013). The evolution of molecular hydrogen: A noteworthy potential therapy with clinical significance. Medical Gas Research, 3(10), 1-12. doi: 10.1186/2045-9912-3-10

 

Oxidative and antioxidative balance in patients of migraine

 

“In this study, we demonstrated that the levels of total antioxidants were decreased and the levels of total oxidants and the oxidative stress index were increased in patients with migraine without aura (MWoA). These findings may be an evidence of exposure to potent oxidative stress in MWoA.”

 

Alp, R., Selek, S., Alp, S., Taskin, A., & Kocyigit, A. (2010). Oxidative and antioxidative balance in patients of migraine. European Review for Medical and Pharmacological Sclences, 14(10), 877-882. Retrieved from https://www.ncbi.nlm.nih.gov/pubmed/21222375

 

Recent progress toward hydrogen medicine: Potential of molecular hydrogen for preventive and therapeutic applications

 

“H2 has a number of advantages as a potential antioxidant: H2 rapidly diffuses into tissues and cells, and it is mild enough neither to disturb metabolic redox reactions nor to affect reactive oxygen species (ROS) that function in cell signaling, thereby, there should be little adverse effects of consuming H2. H2 shows not only effects against oxidative stress, but also various anti-inflammatory and anti-allergic effects. Moreover, H2 passes through the blood brain barrier, although most antioxidant compounds cannot; this is also an advantage of H2.”

 

Ohta, S. (2011). Recent progress toward hydrogen medicine: Potential of molecular hydrogen for preventative and therapeutic applications. Current Pharmaceutical Design, 17(22), 2241-2252. doi: 10.2174/138161211797052664

 

Relationship between oxidative stress and chronic daily headache in children

 

“Mean activities of erythrocyte SOD, CAT, and GPx as well as MDA levels were significantly higher in the study group than in the control group (p < 0.001). The findings of this study suggest that oxidative stress may play a causal or consequential role in children with CDH.”

 

Vurucu, S., Karaoglu, A., Paksu, M., Yesilyurt, O., Oz, O., Unay, B., & Akin, R. (2013). Relationship between oxidative stress and chronic daily headache in children. Human & Experimental Toxicology, 32(2), 113-119. doi: 10.1177/0960327112459204

 

 

Hydrogen acts as a therapeutic antioxidant by selectively reducing cytotoxic oxygen radicals

“Hydrogen selectively reduces the hydroxyl radical, the most toxic free radical, and effectively protects cells. It does not react with free radicals that have physiological benefits, making it an incredibly effective therapy to neutralize acute oxidative stress.”

 

Ohsawa, I., Ishikawa, M., Takahashi, K., Watanabe, M., Nishimaki, K., Yamagata, K., . . . Ohta, S. (2007). Hydrogen acts as a therapeutic antioxidant by selectively reducing cytotoxic oxygen radicals. Nature Medicine, 13(6), 688-694. doi: 10.1038/nm1577  

 

Oxidative stress in migraine with and without aura

 

“Conclusively, in this preliminary study, we had found increased oxidative stress in the migraine patients especially the patients with MWA. Further knowledge about this issue may contribute the cause and complications of migraine and may be essential for development of treatment approaches.”

 

Tuncel, D., Tolun, F., Gokce, M., Imrek, S., & Ekerbicer, H. (2008). Oxidative stress in migraine with and without aura. Biological trace element research, 124(1-3), 92-97. doi: 10.1007/s12011-008-8193-9

 

Hydrogen as a selective antioxidant: A review of clinical and experimental studies

“H2 is emerging as a novel and safe therapeutic antioxidant. It has selective antioxidant properties, giving it anti-inflammatory properties.”

 

Hong, Y., Chen, S., & Zhang, J. (2010). Hydrogen as a selective antioxidant: A review of clinical and experimental studies. Journal of International Medical Research, 38(6), 1893-1903. doi: 10.1177/147323001003800602  

 

Local inflammation as a mediator of migraine and tension-type headache

 

“Ipsilateral intraoral tenderness and increased local temperature were consistently observed during unilateral migraine and tension-type headache, suggesting local inflammation. Intraoral chilling and topical application of a nonsteroidal anti-inflammatory drug were highly effective for the treatment of migraine and tension-type headache, both in the acute phase and for headache prevention. These results suggest that a local intraoral inflammation may be associated with the pathogenesis of these common headaches.”

 

Friedman, M. H. (2004). Local inflammation as a mediator of migraine and tension-type headache. Headache, 44(8), 767-771. doi: 10.1111/j.1526-4610.2004.04143.x

 

A review of hydrogen as a new medical therapy

 

“In the past few years many initial and subsequent clinical studies have demonstrated that hydrogen can act as an important physiological regulatory factor to cells and organs on the antioxidant, anti-inflammatory, anti-apoptotic and other protective effects. So far several delivery methods applied in these studies have proved to be available and convenient, including inhalation, drinking hydrogen-dissolved water and injection with hydrogen-saturated saline.”

 

Zhang, J., Liu, C., Zhou, L., Qu, K., Wang, R., Tai, M., . . . Wang, Z. (2012). A Review of hydrogen as a new medical therapy. Hepatogastroenterology, 59(116), 1026-1032. doi: 10.5754/hge11883

 

Increased nitrosative and oxidative stress in platelets of migraine patients

 

“During migraine attacks, platelet levels of nitrate, nitrite and MDA were significantly higher in migraineurs than these in control subjects (p = 0.042, p = 0.005 and p = 0.042, respectively). By contrast, during headache-free period, no statistically significant differences were found in the platelet levels of nitrate, nitrite and MDA between migraineurs and controls (p > 0.05), although the marginal increases were detected in migraineurs. These results suggest that increased biomarkers of nitrosative and oxidative stress in platelets may be important in migraine patients, especially during attacks; increase of NO metabolites in platelets during attacks supports the opinion that NO may play a modulatory role in biological processes particularly by vasodilatation in migraine attacks.”

 

Yilmaz, G., Sürer, H., Inan, L. E., Coskun, Ö, & Yücel, D. (2007). Increased nitrosative and oxidative stress in platelets of migraine patients. The Tohoku Journal of Experimental Medicine, 211(1), 23-30. doi: 10.1620/tjem.211.23

 

Intrathecal infusion of hydrogen-rich normal saline attenuates neuropathic pain via inhibition of activation of spinal astrocytes and microglia in rats

 

“Intrathecal injection of HRS produced analgesic effect in the rat model of neuropathic pain. Preemptive treatments with HRS delayed the development of pain behavior, and no tolerance developed when HRS was given repeatedly. We conclude that abnormal elevation of ROS and RNS plays a key role in central sensitization under neuropathic conditions. HRS has a potentially promising prospect for clinical treatment of neuropathic pain.”

 

Ge, Y., Wu, F., Sun, X., Xiang, Z., Yang, L., Huang, S., . . . Yu, W. (2014). Intrathecal infusion of hydrogen-rich normal saline attenuates neuropathic pain via inhibition of activation of spinal astrocytes and microglia in rats. PLOS ONE, 9(5), 1-12. doi: 10.1371/journal.pone.0097436

 

A novel oxidative stress marker in migraine patients: Dynamic thiol-disulphide homeostasis

 

“The aim of this study was to investigate dynamic thiol-disulphide homeostasis as a novel oxidative stress parameter in migraine patients. The total and native thiol levels of migraine patients participating in the study were found to be significantly higher than the total and native thiol levels of healthy individuals. Oxidative stress is considered to be one of the molecular changes underlying the pathogenesis of migraine.”

 

Gumusyayla, S., Vural, G., Bektas, H., Neselioglu, S., Deniz, O., & Erel, O. (2016). A novel oxidative stress marker in migraine patients: Dynamic thiol–disulphide homeostasis. Neurological Sciences, 37(8), 1311-1317. doi: 10.1007/s10072-016-2592-z

 

Hydrogen-rich saline attenuated neuropathic pain by reducing oxidative stress

 

“Reactive oxygen species (ROS) are often associated with persistent pains such as neuropathic and inflammatory pain. Hydrogen gas can reduce ROS and alleviate cerebral, myocardial, and hepatic ischemia/reperfusion injuries. Intrathecal injection of hydrogen-rich saline can decrease oxidative stress and the expression of p38MAPK and BDNF that may contribute to the elevated threshold of neuropathic pain in rat CCI model.”

 

Chen, Q., Chen, P., Zhou, S., Yan, X., Zhang, J., Sun, X., . . . Yu, W. (2013). Hydrogen-rich saline attenuated neuropathic pain by reducing oxidative stress. The Canadian Journal of Neurological Sciences, 40(6), 857-863. doi: 10.1017/s0317167100016024

 

Oxidative stress and DNA damage in patients with migraine

 

“No significant differences in TAS, TOS, and OSI values were observed between patients and controls. However, plasma 8-OHdG levels were found to be significantly higher in migraine patients than in the control group (p = 0.001); this increase in plasma 8-OHdG levels was more prominent in cases with migraine without aura than with aura (p = 0.001). Our results suggested an evidence of oxidative stress-related DNA damage in migraine.”

 

Geyik, S., Altunısık, E., Neyal, A. M., & Taysi, S. (2016). Oxidative stress and DNA damage in patients with migraine. The Journal of Headache and Pain, 17(10), 1-6. doi: 10.1186/s10194-016-0606-0

 

 

Molecular hydrogen attenuates neuropathic pain in mice

 

“Accumulating evidence indicates that overproduction of oxidative stress is a key event in the pathogenesis of neuropathic pain.  Immunohistochemical staining for the oxidative stress marker, 4-hydroxy-2-nonenal and 8-hydroxydeoxyguanosine, showed that hydrogen administration suppressed oxidative stress induced by ligation in the spinal cord and the dorsal root ganglion. In conclusion, oral administration of hydrogen water may be useful for alleviating neuropathic pain in a clinical setting.

 

Kawaguchi, M., Satoh, Y., Otsubo, Y., & Kazama, T. (2014). Molecular hydrogen attenuates neuropathic pain in mice. PLOS ONE, 9(6), 1-10. doi: 10.1371/journal.pone.0100352

 

Increased vulnerability to oxidative stress in pediatric migraine patients

 

“Superoxide dismutase, glutathione peroxidase, and catalase activities were measured in erythrocytes. Although superoxide dismutase activities did not differ between groups, both catalase and glutathione peroxidase activities were significantly lower in migraine patients (P = 0.001 and P = 0.009, respectively). Activities of all three antioxidant enzymes were similar across migraine subgroups; there was no correlation with age and sex. These results confirm vulnerability to oxidative stress in pediatric migraine. Further studies and search for new therapeutic agents with antioxidant properties are needed.”

 

Erol, I., Alehan, F., Aldemir, D., & Ogus, E. (2010). Increased vulnerability to oxidative stress in pediatric migraine patients. Pediatric Neurology, 43(1), 21-24. doi: 10.1016/j.pediatrneurol.2010.02.014

 

Hydrogen-rich saline prevents remifentanil-induced hyperalgesia and inhibits MnSOD nitration via regulation of NR2B-containing NMDA receptor in rats

 

“Hyperalgesia and MnSOD nitration were attenuated after the combination of HRS (2.5 ml/kg) and Ro25-6981 (5 μg). In conclusion, HRS (10 ml/kg) might reverse remifentanil-induced hyperalgesia, through regulating NR2B-containing NMDAR trafficking to control MnSOD nitration and enhance MnSOD activity.”

 

Zhang, L., Shu, R., Wang, H., Yu, Y., Wang, C., Yang, M., . . . Wang, G. (2014). Hydrogen-rich saline prevents remifentanil-induced hyperalgesia and inhibits MnSOD nitration via regulation of NR2B-containing NMDA receptor in rats. Neuroscience, 280, 171-180. doi: 10.1016/j.neuroscience.2014.09.024

 

Evidences of reduced antioxidant activity in patients with chronic migraine and medication-overuse headache

 

“The data from the present study suggest that antioxidant capacity is lower in chronic migraine patients and medication-overuse headache compared to healthy headache-free subjects, with no differences between patients with triptan or nonsteroidal anti-inflammatory drug overuse.”

 

Lucchesi, C., Baldacci, F., Cafalli, M., Chico, L., Gerfo, A. L., Bonuccelli, U., . . . Gori, S. (2015). Evidences of reduced antioxidant activity in patients with chronic migraine and medication-overuse headache. Headache, 55(7), 984-991. doi: 10.1111/head.12608

 

Beneficial biological effects and the underlying mechanisms of molecular hydrogen - Comprehensive review of 321 original articles

 

“A total of 321 original articles have been published from 2007 to June 2015. Most studies have been conducted in Japan, China, and the USA. The effects have been reported in essentially all organs covering 31 disease categories that can be subdivided into 166 disease models, human diseases, treatment-associated pathologies, and pathophysiological conditions of plants with a predominance of oxidative stress-mediated diseases and inflammatory diseases.”

 

Ichihara, M., Sobue, S., Ito, M., Ito, M., Hirayama, M., & Ohno, K. (2015). Beneficial biological effects and the underlying mechanisms of molecular hydrogen - Comprehensive review of 321 original articles. Medical Gas Research, 5(12), 1-21. doi: 10.1186/s13618-015-0035-1

© 2018 trusii. All Rights Reserved

The statements on this website have not been evaluated by the Food and Drug Administration.
The products on this website are not intended to diagnose, treat, cure, or prevent any disease.