Performance and Recovery Program
Research & Studies

Pilot study: Effects of drinking hydrogen-rich water on muscle fatigue caused by acute exercise in elite athletes

“HW may be suitable hydration for athletes by preventing elevation of blood lactate during heavy exercise. Adequate hydration with hydrogen-rich water pre-exercise reduced blood lactate levels and improved exercise-induced decline of muscle function.”

 

Aoki, K., Nakao, A., Adachi, T., Matsui, Y., & Miyakawa, S. (2012). Pilot study: Effects of drinking hydrogen-rich water on muscle fatigue caused by acute exercise in elite athletes. Medical Gas Research, 2(12), 1-6. doi: 10.1186/2045-9912-2-12

 

Molecular hydrogen affected post-exercise recovery in judo athletes

“Hydrogen-rich water appears to be an appropriate strategy to positively affect post-exercise lactates in judo athletes.”

Drid, P., Stojanovic, M. D., Trivic, T., & Ostojic, S. M. (2016). Molecular hydrogen affected post-exercise recovery in judo athletes. Medicine and Science in Sports and Exercise, 48(5), 3820-3821. doi: 10.1249/01.mss.0000488223.41775.bc

 

Impact of oxidative stress on exercising skeletal muscle

 

“There is rapidly growing evidence that ROS have both positive and negative effects in contracting skeletal muscle cells. The deleterious effects such as a reduction of force generation and increased muscle atrophy appear to occur particularly after non-regular strenuous exercise, while regular training has positive effects by influencing cellular processes that lead to increased expression of antioxidants. These molecules then provide a better protection from ROS during subsequent trainings.”

 

Steinbacher, P., & Eckl, P. (2015). Impact of oxidative stress on exercising skeletal muscle. Biomolecules, 5(2), 356-377. doi: 10.3390/biom5020356

 

Exercise, oxidative stress and risk of cardiovascular disease in the elderly. Protective role of antioxidant functional foods

 

“Concurrent antioxidant supplementation did not produce any ergogenic effects but, meaningfully, enhanced some positive effects of exercise on physical health and the CDV risk index, and it totally prevented the exercise-induced oxidative stress. Our results show that regular and moderate exercise improves cardiorespiratory function and reduces CVD risk in elderly people, while concurrent antioxidant supplementation modulates oxidative insult during exercise in the elderly and enhances the beneficial effects of exercise.”

 

Galán, A. I., Palacios, E., Ruiz, F., Díez, A., Arji, M., Almar, M., . . . Jiménez, R. (2006). Exercise, oxidative stress and risk of cardiovascular disease in the elderly. Protective role of antioxidant functional foods. BioFactors, 27(1-4), 167-183. doi: 10.1002/biof.5520270115

 

Hydrogen as a selective antioxidant: A review of clinical and experimental studies

“H2 is emerging as a novel and safe therapeutic antioxidant. It has selective antioxidant properties, giving it anti-inflammatory properties.”

 

Hong, Y., Chen, S., & Zhang, J. (2010). Hydrogen as a selective antioxidant: A review of clinical and experimental studies. Journal of International Medical Research, 38(6), 1893-1903. doi: 10.1177/147323001003800602

 

 

The effect of antioxidant supplementation on fatigue during exercise: Potential role for NAD+(H)

 

“The associated increases in both oxidised and reduced NAD+ and time to fatigue following antioxidant supplementation is consistent with the hypothesis that antioxidant supplementation reduces the oxidative stress induced suppression of aerobic respiration within the mitochondria, thereby increasing the efficiency of electron transfer and ATP production.

 

Mach, J., Midgley, A. W., Dank, S., Grant, R. S., & Bentley, D. J. (2010). The effect of antioxidant supplementation on fatigue during exercise: Potential role for NAD (H). Nutrients, 2(3), 319-329. doi: 10.3390/nu2030319

 

Hydrogen-supplemented drinking water protects cardiac allografts from inflammation-associated deterioration

 

“Hydrogen treatment was also associated with increased graft ATP levels and increased activity of the enzymes in mitochondrial respiratory chain.” 

 

Noda, K., Tanaka, Y., Shigemura, N., Kawamura, T., Wang, Y., Masutani, K., . . . Nakao, A. (2012). Hydrogen-supplemented drinking water protects cardiac allografts from inflammation-associated deterioration. Transplant International, 25(12), 1213-1222. doi: 10.1111/j.1432-2277.2012.01542.x

 

Exercise-induced oxidative stress: Cellular mechanisms and impact on muscle force production

 

“Interestingly, low and physiological levels of reactive oxygen species are required for normal force production in skeletal muscle, but high levels of reactive oxygen species promote contractile dysfunction resulting in muscle weakness and fatigue.”

 

Powers, S. K., & Jackson, M. J. (2008). Exercise-induced oxidative stress: Cellular mechanisms and impact on muscle force production. Physiological Reviews, 88(4), 1243-1276. doi: 10.1152/physrev.00031.2007

 

Oxidative stress: Relationship with exercise and training

 

“Physical exercise also increases oxidative stress and causes disruptions of the homeostasis. Training can have positive or negative effects on oxidative stress depending on training load, training specificity and the basal level of training. Moreover, oxidative stress seems to be involved in muscular fatigue and may lead to overtraining.”

 

Finaud, J., Lac, G., & Filaire, E. (2006). Oxidative stress: Relationship with exercise and training. Sports Medicine, 36(4), 327-358. doi: 10.2165/00007256-200636040-00004

 

Hydrogen acts as a therapeutic antioxidant by selectively reducing cytotoxic oxygen radicals

 “Hydrogen selectively reduces the hydroxyl radical, the most toxic free radical, and effectively protects cells. It does not react with free radicals that have physiological benefits, making it an incredibly effective therapy to neutralize acute oxidative stress.”

 

Ohsawa, I., Ishikawa, M., Takahashi, K., Watanabe, M., Nishimaki, K., Yamagata, K., . . . Ohta, S. (2007). Hydrogen acts as a therapeutic antioxidant by selectively reducing cytotoxic oxygen radicals. Nature Medicine, 13(6), 688-694. doi: 10.1038/nm1577

 

Recent progress toward hydrogen medicine: Potential of molecular hydrogen for preventive and therapeutic applications

“H2 prevented the decline of the mitochondrial membrane potential. This suggested that H2 protected mitochondria from OH. Along with this protective effect, H2 also prevented a decrease in the cellular level of ATP synthesized in mitochondria. The fact that H2 protected mitochondria and nuclear DNA provided evidence that H2 penetrated most membranes and diffused into organelles.”

 

Ohta, S. (2011). Recent progress toward hydrogen medicine: Potential of molecular hydrogen for preventive and therapeutic applications. Current Pharmaceutical Design, 17(22), 2241-2252. doi: 10.2174/138161211797052664

 

Drinks with alkaline negative oxidative reduction potential improve exercise performance in physically active men and women: Double-blind, randomized, placebo-controlled, cross-over trial of efficacy and safety

“Drinks with alkaline negative oxidative reduction potential improve exercise performance in physically active men and women by reducing the rate of blood lactate accumulation during and after exercise, increase time to exhaustion, increase serum buffering capacity and not increase prevalence of adverse effects as compared to the control drink.”

 

Ostojić, S. (2011). Drinks with alkaline negative oxidative reduction potential improve exercise performance in physically active men and women: Double-blind, randomized, placebo-controlled, cross-over trial of efficacy and safety. Serbian Journal of Sports Sciences, 5(3), 83-89. Retrieved from https://www.researchgate.net/publication/225183451_DRINKS_WITH_ALKALINE_NEGATIVE_OXIDATIVE_REDUCTION_POTENTIAL_IMPROVE_EXERCISE_PERFORMANCE_IN_PHYSICALLY_ACTIVE_MEN_AND_WOMEN_DOUBLE-BLIND_RANDOMIZEDPLACEBO-CONTROLLED_CROSS-OVER_TRIAL_OF_EFFICACY_AND_SAFETY

 

Hydrogen-rich water affected blood alkalinity in physically active men

“Hydrogen-rich water may be an effective and safe alkalizing agent in the treatment of exercise-induced acidosis.”

 

Ostojic, S. M., & Stojanovic, M. D. (2014). Hydrogen-rich water affected blood alkalinity in physically active men. Research in Sports Medicine, 22(1), 49-60. doi: 10.1080/15438627.2013.852092.

 

Serum alkalinization and hydrogen-rich water in healthy men ​

“Metabolic acidosis during intense exercise results in muscle ache, muscle burning, rapid breathing, nausea and stomach pain. The consumption of hydrogen-rich water by healthy athletes engaging in intense exercise helped to reduce the level of acidosis, suggesting that hydrogen-rich water provides benefits as a neutralizing agent.”

 

Ostojic, S. M. (2012). Serum alkalinization and hydrogen-rich water in healthy men. Mayo Clinic Proceedings, 87(5), 501-502. doi: 10.1016/j.mayocp.2012.02.008 

 

Oxidative stress in skeletal muscle causes severe disturbance of exercise activity without muscle atrophy

 

“The increase in reactive oxygen species (ROS) levels that occurs during intense exercise has been proposed to be one of the major causes of muscle fatigue. A single administration of the antioxidant EUK-8 significantly improved exercise activity and increased the cellular ATP level in skeletal muscle. These results imply that the superoxide anions generated in mitochondria play a pivotal role in the progression of exercise intolerance.”

 

Kuwahara, H., Horie, T., Ishikawa, S., Tsuda, C., Kawakami, S., Noda, Y., . . . Okabe, M. (2010). Oxidative stress in skeletal muscle causes severe disturbance of exercise activity without muscle atrophy. Free Radical Biology and Medicine, 48(9), 1252-1262. doi: 10.1016/j.freeradbiomed.2010.02.011

 

 

Molecular hydrogen in sports medicine: New therapeutic perspectives

“In the past 2 decades, molecular hydrogen emerged as a novel therapeutic agent, with antioxidant, anti-inflammatory and anti-apoptotic effects demonstrated in plethora of animal disease models and human studies. In particular, hydrogen therapy may be an effective and specific innovative treatment for exercise-induced oxidative stress and sports injury, with potential for the improvement of exercise performance.”

 

Ostojic, S. (2014). Molecular hydrogen in sports medicine: New therapeutic perspectives. International Journal of Sports Medicine, 36(4), 273-279. doi: 10.1055/s-0034-1395509

 

Altered oxidative stress in overtrained athletes

 

“These results suggest that increased oxidative stress has a role in the pathophysiology of overtraining syndrome. The attenuated responses of oxidative stress and antioxidant capacity to exercise in the overtrained state could be related to an inability to perform exercise effectively and impaired adaptation to exercise.”

 

Tanskanen, M., Atalay, M., & Uusitalo, A. (2010). Altered oxidative stress in overtrained athletes. Journal of Sports Sciences, 28(3), 309-317. doi: 10.1080/02640410903473844

 

Effectiveness of oral and topical hydrogen for sports-related soft tissue injuries


“Oral and topical hydrogen intervention was found to augment plasma viscosity decrease as compared with the control group (P = 0.04). Differences were found for range-of-motion recovery between the 3 groups; oral and topical hydrogen intervention resulted in a faster return to normal joint range of motion for both flexion and extension of the injured limb as compared with the control intervention (P < 0.05). These preliminary results support the hypothesis that the addition of hydrogen to traditional treatment protocols is potentially effective in the treatment of soft tissue injuries in male professional athletes.”

Ostojic, S. M., Vukomanovic, B., Calleja-Gonzalez, J., & Hoffman, J. R. (2014). Effectiveness of oral and topical hydrogen for sports-related soft tissue injuries. Postgraduate Medicine, 126(5), 188-196. doi: 10.3810/pgm.2014.09.2813

 

Effect of treadmill exercise and hydrogen-rich water intake on serum oxidative and anti-oxidative metabolites in serum of thoroughbred horses

“The present study aimed to clarify changes of oxidative stress and antioxidative functions in treadmill-exercised Thoroughbred horses using recently developed techniques for measurement of oxidative stress and antioxidative markers. Also, the effect of nasogastric administration of hydrogen-rich water (HW) or placebo water preceding the treadmill exercise on these parameters was examined. The marked elevation of oxidative stress and anitioxidative functions occurred simultaneously in the intensively exercised horses, and suggest a possibility that HW has some antioxidative efficacy.”

 

Tsubone, H., Hanafusa, M., Endo, M., Manabe, N., Hiraga, A., Ohmura, H., & Aida, H. (2013). Effect of treadmill exercise and hydrogen-rich water intake on serum oxidative and anti-oxidative metabolites in serum of thoroughbred horses. Journal of Equine Science, 24(1), 1-8. doi: 10.1294/jes.24.1

© 2018 trusii. All Rights Reserved

The statements on this website have not been evaluated by the Food and Drug Administration.
The products on this website are not intended to diagnose, treat, cure, or prevent any disease.